Chemistry 310 Spring 2009
Enzyme Mechanisms
Prof.
Bryan Hanson
Note: this page will be updated regularly as the future comes into focus! Check back often. Last update: April 17, 2009
Problems that are assigned will not be collected or graded.
We will spend somewhere between 1/3 & 1/2 of the course covering Chapter 1. This is a very short and terse chapter because the authors assume you have had a full year of organic chemistry. We will work it slowly, add in lots of handouts, and work lots of problems.
| Week | Topics | Assignments |
| Week of Jan 26th | Orientation to the course. Acids & bases & factors affecting same. | Read sec 1.1. Be sure you know Table 1.1 perfectly (possible quiz material). We won't discuss this material in class. Read sec 1.2 through pg 10. Work problems 1.1 (except f), 1.5, 1.6. |
Week of Feb 2nd |
Nucleophlles & electrophiles. Electrophilic addition rxns. | Read sec 1.2, pg 11. Read sec. 1.3. In Chapter 1, try the arrow pushing exercises in problems 1.7, 1.8ac (in these B: is a generic base). On your own, review all of Chap 2 and make certain you know this material (it is review from Chem 240). Work problems 2.1, 2.2, 2.3, 2.6, 2.7, 2.11, 2.14, 2.17, 2.18, 2.19, 2.20, 2.21. |
| Week of Feb 9th | Nucleophilic substitution rxns. | Read sec 1.4. Try problem 1.15 - focus on what bonds are being made & broken. Start on sec 1.5, we'll continue it next week. |
| Week of Feb 16th | Nucleophilic additions to carbonyls (aldehydes & ketones). | Continue reading sec 1.5. We won't finish it before the exam, so not all of it will be on the exam. Try problems 1.12 (1st step only), 1.15, 1.16. Exam 1 is Friday Feb 20th |
| Week of Feb 23rd | Nucleophilic additions to carbonyls (aldehydes & ketones), continued. | Continue studying sec 1.5. Try problem 1.12, 1.14 |
| Week of Mar 2nd | Nucleophilic substitutions on carbonyls | Read sec 1.6 |
| Week of Mar 9th | Condensations using enolates, w/ elimination reactions worked in there too. | Read the rest of Chapter 1 (condensations & eliminations). Try problems 1.7c, 1.8, 1.9, 1.10, 1.13. Some of these you have already worked, but you now have a fuller understanding of what's going on. Also, several of these involve reverse or retro-Claisen & retro-aldol condensations. |
| Week of Mar 16th | Review problems on M & W | Exam 2 is Friday Mar 20th |
| Week of Mar 30th | Fatty acid synthesis & degredation
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Read 3.1, 3.4, 3.3. We will go over the parts of these sections that are new (synthesis of AcCoA, malonyl CoA, FADH2 mechanism) but everything else should look very familiar to the PKS reactions we covered. Try problems 3.1, and 3.14, 3.15, for these last two use Chimera, not Swiss PDB. Friday we will begin looking at the big picture of carbohydrate reactions & the fates of pyruvate... which we'll continue next week (see the box below for the reading) |
| Week of Apr 6th | Reactions of pyruvate & related cofactors; the big picture of glycolysis and TCA, and the Calvin cycle | Read 4.3 about "Fates of Pyruvate" - this will be our first main focus in class. Read 4.1, 4.2, & 4.4. You know the mechanisms of all these reactions and should be able to follow the text and diagrams. You are responsible for these mechanisms (not the paths/cycles), but I will not cover them in class. Our other main focus in class, continuing into next week, will be the Calvin Cycle, so read 4.7 after you have done the other reading. Problems in Chapter 4: 1, 2, 3, 5, 6, 7, 8, 9 |
| Week of Apr 13th | Continue material from previous week, and questions for the exam. | Exam 3 is Friday Apr 17th will cover through Chapter 4, carbohydrate chemistry |
| Week of Apr 20th | Transamination & the Urea Cycle DERA paper |
Please read sections 5.1, 5.2 for Monday & Wednesday. Friday we will start discussing the paper on DERA (download instructions provided via e-mail) |
| Week of Apr 27th | DERA paper | |
| Week of May 4th | ||
| Week of May 11th | Final Exam is Monday May 11th from 8:30-11:30 |
Last updated Sunday, August 23, 2009 . Contents & layout copyright 2009 Prof. Bryan Hanson